Cross-sectional, clinic based
Properties of the Impact of Vision Impairment and Night Vision Questionnaires Among People With Intermediate Age-Related Macular Degeneration
Study Aim : To explore the impact of intermediate AMD on QoL.
Language: English
Comments: Early AMD was not associated with VRQoL.
The impact of vision impairment on vision-specific quality of life in Germany
Study Aim : To determine the relationship between the severity of vision impairment, ocular conditions, and VRQoL.
Language : German
Comments: Even mild vision impairment was independently associated with poor VRQoL.
Assessment of the impact of keratoconus on vision-related quality of life
Study Aim : To investigate if VRQoL varied with disease severity in a sample with keratoconus.
Language : English, Telugu, Hindi
Comments: Patients with moderate or severe keratoconus had similar, but higher VRQoL scores as assessed by the revised IVI subscales.
The relative impact of vision impairment and cardiovascular disease on quality of life: the example of pseudoxanthoma elasticum
Study Aim : To investigate the impact of pseudoxanthoma elasticum (PXE), a rare hereditary disease of concurrent vision impairment (VI) and cardiovascular complications (CVCs), on VRQoL.
Language : English,
Comments: Vision impaired patients with PXE report significantly poorer vision-specific functioning than PXE patients without VI.
Association of Vision-related Quality of Life with Visual Function in Age-Related Macular Degeneration
Study Aim : To assess which visual function measures are most strongly associated with VRQoL in AMD.
Language : German
Comments: Subjects with late AMD had significant lower IVI scores on all subscales compared with intermediate and early AMD.
The Impact of Vision Impairment (IVI) Questionnaire; Validation of the Thai-Version and the Implementation on Vision-Related Quality of Life in Thai Rural Community
Study Aim : To evaluate the impact of VI on VRQoL in southern Thailand.
Language : Thai
Comments: The symptoms of the common vision impairment diseases are associated with an adverse impact on VRQoL in a clinic-based population as demonstrated in this study.
Differential Impact of Unilateral and Bilateral Classifications of Diabetic Retinopathy and Diabetic Macular Edema on Vision-Related Quality of Life
Study Aim : To evaluate and compare the impact of unilateral better-eye and bilateral categorizations of diabetic retinopathy (DR) and diabetic macular edema (DME) on VRQoL.
Language : English, Mandarin
Comments: Unilateral better-eye classifications, multivariable linear models revealed a 9% reduction in VRQoL for any DR and a 17% reduction for any DME. Bilateral categorizations revealed significant decrements in VRQoL that occurred only when both eyes had either DR or DME (11%), which worsened when both eyes were affected by DME (22%).
High vision-related quality of life indices reduce the odds of depressive symptoms in aged care facilities
Study Aim : To examine the association between VRQoL and depressive symptoms in residents with vision impairment (VI) in aged care facilities.
Language : English
Comments: Better vision-related Mobility was associated with reduced odds of depressive symptoms. With every unit improvement in vision-related Reading and Emotional, severity of depressive symptoms reduced, independent of sociodemographic and medical issues.
Vision-specific distress and depressive symptoms in people with vision impairment
Study Aim : To determine the unique contribution of vision-specific distress in predicting depressive symptoms in people with vision impairment attending a tertiary eye care clinic.
Language : English
Comments: Vision-specific distress was the strongest unique predictor of depressive symptoms. vision-specific distress mediates the impact of participation restriction due to vision impairment on depressive symptoms
Psychosocial assessment of potential retinal prosthesis trial participants
Study Aim : To select tests that assess the psychosocial aspects of visual impairment.
Language : English
Comments: IVI was completed without floor or ceiling effects and with minimal respondent burden.
Using Uniocular Visual Acuity Substantially Underestimates the Impact of Visual Impairment on Quality of Life Compared with Binocular Visual Acuity
Study Aim : Population-based study to compare the impact of distance presenting binocular VA and uniocular VA in the better-seeing (better-eye VA) and worse-seeing (worse-eye VA) eye on VRQoL.
Language : English, Mandarin
Comments: Uniocular VA seems to underestimate the impact of vision loss on VRQoL indices compared with binocular VA.
The determinants of participation in activities of daily living in people with impaired vision
Study Aim : To investigate the determinants of participation in daily activities in people with impaired vision.
Language : English
Comments: Distance VA and physical and mental health explained more than a third of the variance of the total score.
Vision-Related Quality of Life in Keratoconus: A Save Sight Keratoconus Registry Study
Study Aim : To assess VRQoL in patients with keratoconus.
Language : English
Comments: BCVA in the better eye had the strongest correlation with reading and mobility scores, whereas BCVA in the worse eye was significantly correlated with emotional scores.
Predicting the need for low vision rehabilitation services
Study Aim : To determine the independent predictors of rehabilitation needs for people with low vision.
Language: English
Comments: In all regression models, VA, the impact of comorbidities on daily living and dependence on family/friends emerged as the three strongest independent predictors of rehabilitation needs.
Prevalence, risk factors and impact of posterior staphyloma diagnosed from wide-field optical coherence tomography in Singapore adults with high myopia
Study Aim : Population-based study to investigate the prevalence and risk factors of posterior staphyloma using wide-field optical coherence tomography (WF-OCT) in adults with high myopia.
Comments: Adults with posterior staphyloma had worse IVI Reading scores.
Methods for estimating personal costs of disease using retinal diseases as an example
Study Aim : To assess personal cost and vision-related quality of life in patients with AMD, DRP or retinal dystrophy.
Language : German
Comments: Vision-related quality of life decreased with increasing visual disability especially in the IVI subscales mobility and independence as well as reading and accessing information.
Associations between glaucomatous visual field loss and participation in activities of daily living
Study Aim : To investigate the association between visual field loss and participation in daily activities in individuals with glaucoma.
Language : English
Comments: There was no independent relationship between visual field loss and IVI score except for the mobility domain. Mobility was the most affected domain of the IVI.
Beyond vision loss: the independent impact of diabetic retinopathy on vision-related quality of life in a Chinese Singaporean population
Study Aim : To assess the independent impact of diabetic retinopathy (DR) on three domains of VRQoL in a Chinese Singapore population.
Language : English, Mandarin
Comments: DR, particularly VTDR, was independently associated with restrictions in Reading and Emotional well-being.
Association of Vision Impairment and Major Eye Diseases With Mobility and Independence in a Chinese Population
Study Aim : To assess the association of VI and major eye diseases with mobility and independence (M&I) in a Chinese population.
Language : English, Mandarin
Comments: Bilateral VI in this population was associated with substantial decrements in M&I, with glaucoma and cataract independently associated with worse M&I.
Vision impairment and major eye diseases reduce vision-specific emotional well-being in a Chinese population
Study Aim : To assess the relationship between vision impairment (VI) and major eye diseases, with vision-specific emotional well-being in a Chinese population
Language : English, Mandarin
Comments: Severe VI and glaucoma are associated with substantial decrements in vision-specific emotional well-being.
Identifying distinct risk factors for vision-specific distress and depressive symptoms in people with vision impairment
Study Aim : To determine the relative importance and associated risk factors of vision-specific distress and depressive symptoms in people with visual impairments.
Language : English
Comments: Vision-specific distress is related to a person's ability to manage the practical and social challenges of vision impairment.
Beyond Intraocular Pressure: Visual Functioning and Quality of Life in Primary Congenital Glaucoma and Secondary Childhood Glaucoma
Study Aim : To compare the visual functioning (VF) and VRQoL of children 8-18 years old treated for primary congenital glaucoma (PCG) and secondary childhood glaucoma.
Language : English
Comments: Children with PCG reported significantly better VF and VRQoL than secondary childhood glaucoma patients. Secondary childhood glaucoma to be associated with worse VF and VRQoL compared to PCG.
Functional Visual Ability and Quality of Life in Children With Glaucoma
Study Aim : To evaluate the effect of glaucoma and its management on the functional visual ability (FVA) and the VRQoL in children 8-18 years of age.
Language : English Telugu, Hindi
Comments:VR QoL as perceived by children with glaucoma are reduced. Children with lower BCVA, those with bilateral glaucoma, and those who had undergone 3 or more glaucoma surgeries had significantly lower VR QoL.
Functional vision and quality of life in children with microphthalmia/anophthalmia/coloboma-a cross-sectional study
Study Aim : To determine the child's perceptions of vision-related quality of life (VR-QoL, in children with microphthalmia/anophthalmia/coloboma (MAC).
Language : English
Comments: VR-QoL and HR-QoL are greatly reduced, with an IVI-C median score of 63.
Quality of Life and Functional Vision in Children with Glaucoma
Study Aim : To evaluate the effect of glaucoma VRQoL in children up to 16 years of age with glaucoma.
Language : English
Comments: Scores for VR QoL were reduced in children with glaucoma.
Quality of life and functional vision in children treated for cataract-a cross-sectional study
Study Aim : To determine VRQOL impact in children aged 2-16 years treated for developmental or secondary cataract.
Language : English
Comments: All scores are markedly reduced: Cataract has a marked a long-term impact on functional visual ability and quality of life of children and young people.
Intervention studies (non-randomised)
Outcomes After Comprehensive Vision Rehabilitation Using Vision-related Quality of Life Questionnaires: Impact of Vision Impairment and National Eye Institute Visual Functioning Questionnaire
Study Aim : Prospective clinical cohort study in people with low vision to evaluate change in patient-reported outcomes after LVR.
Language: English
Comments: IVI scores increased following intervention for LVR.
Impact of type I Boston keratoprosthesis implantation on vision-related quality of life
Study Aim : Prospective clinical cohort study to determine the impact of type I Boston keratoprosthesis (KPro) implantation on VRQoL.
Language : English/Mandarin
Comments: IVI scores increased following treatment.
Outcomes of Multidisciplinary Low Vision Rehabilitation in Adults
Study Aim : To evaluate the outcomes of multidisciplinary low vision rehabilitation (LVR) in adults with low vision (LV) in India
Language : English, Telugu, Hindi
Comments: Significant improvements in VRQoL with large ES for reading and accessing information and relatively moderate ES for overall IVI and mobility subscale No significant improvement was found on emotional well-being subscale.
Evaluating the effectiveness of multidisciplinary low-vision rehabilitation
Study Aim : To objectively evaluate the changes in VRQoL after multidisciplinary low-vision rehabilitation.
Language: English
Comments: No improvement in both the overall score and the mobility subscale at 30 days follow-up, but a significant improvement at 3 months follow-up.
The impact of anti-vascular endothelial growth factor treatment on quality of life in neovascular age-related macular degeneration
Study Aim : Prospective case series to assess the impact of anti-vascular endothelial growth factor (VEGF) treatment in routine medical practice on VRQoL in neovascular age-related macular degeneration (AMD).
Language : English
Comments: Anti-VEGF treatment for neovascular AMD improves patients' VRQoL in those who gain vision and maintains VRQoL in those who maintain VA in their treated eye, irrespective of whether the worse or better eye is treated.
Intervention studies (randomised)
A randomised controlled trial of a self-management programme for low vision implemented in low vision rehabilitation services
Study Aim : PTo investigate the effectiveness of a low vision self-management programme (LVSMP) in older adults.
Language: English
Comments: At one and six month follow-up assessments, no significant between-group differences were found for vision-specific QoL, emotional well-being.
Effectiveness of the "living successfully with low vision" self-management program: Results from a randomized controlled trial in Singaporeans with low vision
Study Aim : To determine the effectiveness of the "Living Successfully with Low Vision" (LSLV) self-management program to improve patient-reported outcomes in Singaporeans.
Language : English/Mandarin
Comments: At 2 weeks, LSLV participants alone experienced a significant within-group improvement in the mean IVI Emotional score but not at 6 months.
Vision-Related Quality of Life Outcomes in the BEVORDEX Study: A Clinical Trial Comparing Ozurdex Sustained Release Dexamethasone Intravitreal Implant and Bevacizumab Treatment for Diabetic Macular Edema
Study Aim : Phase 2, prospective, multicenter, randomized, single-masked clinical trial to determine the patient-centered effectiveness of treatment with the slow-release dexamethasone intravitreal implant (DEX implant) and intravitreal bevacizumab.
Language : English
Comments: Vision-related quality of life improved significantly the reading, mobility, and emotional well-being scales from baseline to 24 months,. There was no significant between-group difference in improvement in VRQoL in the DEX implant only compared with the bevacizumab-only group, in any of the three scales.
Impact of cataract surgery on quality of life in patients with early age-related macular degeneration
Study Aim : To investigate if cataract surgery improves overall and specific areas of QoL in patients with early AMD randomized to either "early surgery" or "standard surgery" (standard cataract surgery waiting time of 6 months).
Language: English
Comments: The standard surgery group systematically recorded worse scores at 6 months on all QoL measures whereas the early surgery group recorded significant gains.
Adding access to a video magnifier to standard vision rehabilitation: initial results on reading performance and well-being from a prospective, randomized study
Study Aim : To evaluate the effect of access to a video magnifier (VM) added to standard comprehensive vision rehabilitation (VR).
Language : English
Comments: All subjects reported better well-being on the IVI.
A randomized clinical trial of intravitreal bevacizumab versus intravitreal dexamethasone for diabetic macular edema: the BEVORDEX study
Study Aim : Phase 2, prospective, multicenter, randomized, single-masked clinical trial to compare dexamethasone implant versus bevacizumab for center-involving diabetic macular edema (DME).
Language : English
Comments: Significant improvement in IVI scores occurred for both treatment groups.
Longitudinal studies
The longitudinal impact of macular telangiectasia (MacTel) type 2 on vision-related quality of life
Study Aim : To determine the longitudinal impact of idiopathic macular telangiectasia (MacTel) type 2 on VRQoL.
Language: English
Comments: The control group had almost twice the level of vision-specific QoL than did the MacTel group at baseline on all IVI scores (P < 0.001 for all). At 24 months, we found no significant change in any of the IVI scores in the MacTel group.
The Influence of Coping on Vision-Related Quality of Life in Patients With Low Vision: A Prospective Longitudinal Study
Study Aim : To determine the longitudinal impact of specific coping strategies on VRQoL in patients with low vision.
Language : English
Comments: Avoidant coping was a significant determinant of decline in vision-related functioning and emotional well-being over a 6-month period.
Change in vision-related quality of life and influencing factors in Asians receiving treatment for neovascular age-related macular degeneration
Study Aim : To assess the change in VRQoL after treatment for neovascular age-related macular degeneration (nAMD).
Language: English, Mandarin
Comments: Reading, Mobility and Emotional demonstrated positive changes after treatment. Improvements in Mobility and Emotional Scores appear to be driven by factors other than visual acuity.
Association between Patient-Reported Outcomes and Time to Late Age-Related Macular Degeneration in the Laser Intervention in Early Stages of Age-Related Macular Degeneration Study
Study Aim : Exploratory analyses from a multicenter randomized controlled trial of an AMD intervention to investigate the relationship between patient-reported outcome (PRO) questionnaire responses and time to late age-related macular degeneration (AMD; neovascular AMD [nAMD] or multimodal imaging [MMI]-defined atrophy) among individuals with bilateral large drusen, and the prognostic value of baseline PROs for 36-month AMD status.
Language : English
Comments: Higher IVI-28 scores were associated with a lower risk of progression to MMI-defined atrophy Baseline IVI-28 scores were found to contribute to the prognosis of atrophy at the 36-month visit.